Learn how aspartame and sucralose can trigger migraines, which sweeteners to avoid, and safer drink alternatives. Does diet coke have aspartame? Does diet coke have sugar? Β· diet coke and other sodas which contain artificial sweetener may be increasing your risk for stroke and heart disease. The risk is tied to the ingredient aspartame (getty) Aspartame – found diet coke , pepsi max and sprite, as well as products like extra chewing gum – has long been linked to health concerns including cancer, high blood pressure and stroke. Some other diet drinks on the market use different low- or no-cal. Β· diet sodas may be worsening your headaches. Β· though the fda approves artificial sweeteners used in diet drinks, there are possible health risks associated with their use. Does diet coke have a calorie-free sweetener? Limiting or avoiding them is your best bet, and its easier now than ever to do so, as there are so many excellent alternatives. Β· aspartame is one of the most common sweeteners and is widely used in low-calorie food and drinks like diet coke and diet pepsi because, although it does contain calories like regular sugar,. Β· in lieu of sugar, diet coke and diet pepsi employ aspartame , an artificial sweetener that imparts sweetness sans calories. Β· while, yes, diet coke doesnt contain real sugar, it can still mess with your metabolism and even lower satiety hormones like glp-1, which in turn, causes you to feel hungrier, riley says.